John LaPres is a Professor in the Department of Biochemistry and Molecular Biology. His research focuses on the PAS (named for the first identified members, Per, ARNT, and Sim) superfamily of transcription factors.
Dr. LaPres received his Ph.D. in Pharmacology from Northwestern University and completed his postdoctoral training at the University of Wisconsin. At MSU, Dr. LaPres is also the Director of BioMolecular Science Gateway Program. The BioMolecular Science Gateway offers admission to six graduate programs: Biochemistry and Molecular Biology, Cell and Molecular Biology, Genetics and Genome Sciences, Microbiology and Molecular Genetics, Pharmacology and Toxicology, and Physiology.
The LaPres laboratory aims to understand the signaling cascades of certain PAS proteins and how they mediate their pleiotropic effects on biological systems. The lab’s research focuses specifically on HIF1a and AHR, and the role they play in modulating the toxicity of metals and dioxins, respectively. The goal of the LaPres Lab is to identify novel proteins and signaling cascades that might influence these two transcription factors and therefore, control their ability to mediate normal biological responses and aberrant signaling leading to toxicity.