The overall goals of Experimental Therapeutics research at Michigan State University are to identify novel molecular targets for cancer, focus on drug development, and foster interaction between basic, translational, and clinical scientists. Spartans will develop innovative and effective anti-cancer therapies.
Research Topics
- Metabolic and proteasome targets in neuroblastoma (Bachmann)
- New compounds that target pathways for chemoprevention (J. Bernard)
- Polymeric-based drug delivery and tissue engineering platforms in cancer (Chan)
- Superparamagnetic iron oxide nanoparticles (Chen)
- Clinical trials in multiple myeloma (Cole)
- Selective estrogen receptor modulators in uterine and breast cancer (Conrad)
- Extracellular vesicles for the targeted delivery of oligonucleotide therapeutics (Harada)
- Immunotherapy and small molecule inhibitor clinical trials in lung cancer (Hrinzenko)
- Targeted drug delivery aided by nanoparticles (Huang)
- Inhibitors of proteasome assembly in multiple myeloma (Isaac)
- Engineering extracellular vesicles as a novel gene delivery tool (Kanada)
- Inorganic nanoparticle and particle engineering for targeted drug delivery (Kim)
- Develop and test new drugs for the prevention or treatment of cancer (Liby)
- Fluorescent molecules that can be manipulated for toxicity against cancer cells (R. Lunt)
- Personalized treatments for cancer-based on metabolic targeting (S. Lunt)
- Small-molecule inhibitors of kinases and autophagy (MacKeigan)
- Nano-patterned substrates for drug screening and therapeutic applications (Mahmoudi)
- Autophagy inhibition as a therapeutic strategy (Martin)
- Bioassay-directed discovery and characterization of natural products (Nair)
- Novel mechanisms to control GPCR function and chemical inhibitors in melanoma (Neubig)
- Gene transcription inhibitors with efficacy in melanoma models (Lisabeth)
- Chemokine-based immunotherapies to treat cancer (Pyeon)
- Novel nanotechnology-based strategies and therapeutic agents for cancer (Smith)
- Synthesis of natural products and medicinal chemistry as anti-cancer agents (Tepe)
- Small-molecule binding and docking techniques to understanding target predictions (Wilson)