Andrea Doseff is a Professor in the Department of Physiology. Her research focuses on the mechanisms that regulate apoptosis and cell fate. Dr. Doseff is also the Director of the Graduate Program in Physiology.
Dr. Doseff received her Ph.D. through a joint program at the State University of New York at Stony Brook and Cold Spring Harbor Laboratory. She also received her postdoctoral training at Cold Spring Harbor Laboratory. Prior to joining MSU, she was a Professor at Ohio State University, where she started her academic career as an Assistant Professor.
The Doseff lab uses genome-wide analyses, proteomics, molecular, biochemical, cellular and animal models to elucidate how cell death proteins and its regulators define cell fate, reduce cancer resistance and control immune-function. Additionally, the lab investigates the role of plant compounds (phytochemicals) in the regulation of immune cell function. Dr. Doseff’s research revealed the role of phytochemicals in halting cancer development and metastasis by modulating gene expression and RNA splicing. The lab conducts research in functional foods that increase the efficacy of phytochemicals, thereby facilitating alternative approaches for cancer prevention and treatment, in addition to other inflammatory diseases.