Edmund Ellsworth, Ph.D., directs the MSU Medicinal Chemistry Facility and is a Professor in the Department of Pharmacology and Toxicology. Dr. Ellsworth’s work supports early drug discovery, including the development of new and novel chemistries for therapeutic application in cancer and other diseases.

Ellsworth earned his Ph.D. in Organic Chemistry from the University of California. He completed his postdoctoral training as an NIH post-doctoral fellow at Harvard University. Prior to joining MSU, Dr. Ellsworth was a scientist and leader in the pharmaceutical industry holding positions at Parke-Davis, Pfizer, and Zoetis.


As director of the MSU Medicinal Chemistry Facility, Dr. Ellsworth collaborates with MSU faculty and external collaborators for chemical biology, high-throughput screening outcome triage, lead development, template hopping, structure activity relationship (SAR) development, structure-based design, route development and scale-up. The medicinal chemistry facility bridges the drug discovery gap that often exists between basic research and preclinical drug development. Dr. Ellsworth’s group has a breadth of expertise in small molecules, peptides, natural products, and macrolides using modeling, chemoinformatics, traditional synthesis strategies, parallel medicinal chemistry methods, ADME optimization and pharmacokinetics which support the cancer research being conducted at MSU.

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